From 1949 until 1988, the Soviet Union conducted a nearly continuous campaign of false allegations of biological-weapon (BW) use by the United States. In 1995, senior Russian military officials revived this pattern of false allegations, which continues to the present day. Russian officials amplified the campaign after the US government funded the transformation of former Soviet BW facilities in the Commonwealth of Independent States under the Nunn–Lugar program. The outbreak of the COVID-19 pandemic in China in January 2020 prompted a very greatly expanded Russian-government BW-related disinformation effort. This paper aims to present a reasonably comprehensive account of these activities and to assess their significance. The Russian government under President Vladimir Putin has demonstrated open disdain for both the Biological and Toxin Weapons Convention and the Chemical Weapons Convention.